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61.
62.
Najjar Morvarid Hosseini Hasan Ali Masoudi Abdolhossein Hashemzadeh Alireza Darroudi Majid 《Research on Chemical Intermediates》2020,46(4):2155-2168
Research on Chemical Intermediates - In this research, tin oxide nanoparticles (SnO2-nanoparticles) are synthesized using sol–gel method in polymeric bed and considering the principals of... 相似文献
63.
Mehfooz Haroon Saeed Aamer Faisal Muhammad Larik Fayaz Ali Muqadar Urooj Khatoon Saira Channar Pervaiz Ali Ismail Hammad Bilquees Salma Rashid Sajid Shafique Shagufta Mirza Bushra Dilshad Erum Ahmad Fawad 《Research on Chemical Intermediates》2020,46(5):2437-2456
Research on Chemical Intermediates - Meldrum’s acid derivatives were facile synthesized by one-pot condensation process and characterized by NMR (1H, 13C, DEPT-90 and DEPT-135) and EI-MS. The... 相似文献
64.
Nasseri Mohammad Ali Ramezani-Moghadam Simin Kazemnejadi Milad Allahresani Ali 《Research on Chemical Intermediates》2020,46(9):4233-4256
Research on Chemical Intermediates - A new multifunctional bimetallic nanocatalyst was prepared by immobilization of Cu/Ni-doped sulfated zirconium oxide on magnetic cadmium ferrite... 相似文献
65.
Roger M. Bialy Dr. Monsur M. Ali Prof. Dr. Yingfu Li Prof. Dr. John D. Brennan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(22):5085-5092
We report a method to detect proteins via suppression of rolling circle amplification (RCA) by using an appropriate aptamer as the linear primer (denoted as an aptaprimer) to initiate RCA. In the absence of a protein target, the aptaprimer is free to initiate RCA, which can produce long DNA products that are detected via binding of a fluorescent intercalating dye. Introduction of a target causes the primer region within the aptamer to become unavailable for binding to the circular template, inhibiting RCA. Using SYBR Gold or QuantiFluor dyes as fluorescent probes to bind to the RCA reaction product, it is possible to produce a generic protein-modulated RCA assay system that does not require fluorophore- or biotin-modified DNA species, substantially reducing complexity and cost of reagents. Based on this modulation of RCA, we demonstrate the ability to produce both solution and paper-based assays for rapid and quantitative detection of proteins including platelet derived growth factor and thrombin. 相似文献
66.
Prof. Dr. Qian Miao Dr. Farzaneh Rouhani Dr. Hamed Moghanni-Bavil-Olyaei Dr. Kuan-Guan Liu Xue-Mei Gao Jing-Zhe Li Xiu-De Hu Prof. Dr. Zhi-Min Jin Prof. Mao-Lin Hu Prof. Ali Morsali 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(43):9518-9526
As redox-active based supercapacitors are known as highly desirable next-generation supercapacitor electrodes, the targeted design of two ferrocene-functionalized (Fc(COOH)2) clusters based on coinage metals, [(PPh3)2AgO2CFcCO2Ag(PPh3)2]2 ⋅ 7 CH3OH (SC1: super capacitor) and [(PPh3)3CuO2CFcCO2Cu(PPh3)3] ⋅ 3 CH3OH (SC2), is reported. Both structures are fully characterized by various techniques. The structures are utilized as energy storage electrode materials, giving 130 F g−1 and 210 F g−1 specific capacitance at 1.5 A g−1 in Na2SO4 electrolyte, respectively. The obtained results show that the presence of CuI instead of AgI improves the supercapacitive performance of the cluster. Further, to improve the conductivity, the PSC2 ([(PPh3)2CuO2CFcCO2]∞), a polymeric structure of SC2, was synthesized and used as an energy storage electrode. PSC2 displays high conductivity and gives 455 F g−1 capacitance at 3 A g−1. The PSC2 as a supercapacitor electrode presents a high power density (2416 W kg−1), high energy density (161 Wh kg−1), and long cycle life over 4000 cycles (93 %). These results could lead to the amplification of high-performance supercapacitors in new areas to develop real applications and stimulate the use of the targeted design of coordination polymers without hybridization or compositions with additive materials. 相似文献
67.
Hafiz Saqib Ali Dr. Richard H. Henchman Dr. Sam P. de Visser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(57):13093-13102
A recently characterized cytochrome P450 isozyme GcoA activates lignin components through a selective O-demethylation or alternatively an acetal formation reaction. These are important reactions in biotechnology and, because lignin is readily available; it being the main component in plant cell walls. In this work we present a density functional theory study on a large active site model of GcoA to investigate syringol activation by an iron(IV)-oxo heme cation radical oxidant (Compound I) leading to hemiacetal and acetal products. Several substrate-binding positions were tested and full energy landscapes calculated. The study shows that substrate positioning determines the product distributions. Thus, with the phenol group pointing away from the heme, an O-demethylation is predicted, whereas an initial hydrogen-atom abstraction of the weak phenolic O-H group would trigger a pathway leading to ring-closure to form acetal products. Predictions on how to engineer P450 GcoA to get more selective product distributions are given. 相似文献
68.
Dr. Jiaqing Wang Weiyi Tan Dr. Guanying Li Difei Wu Hongjian He Jiashu Xu Meihui Yi Prof. Dr. Ye Zhang S. Ali Aghvami Prof. Dr. Seth Fraden Prof. Dr. Bing Xu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(66):15116-15120
Although lipids contribute to cancer drug resistance, it is challenging to target diverse range of lipids. Here, we show enzymatically inserting exceedingly simple synthetic lipids into membranes for increasing membrane tension and selectively inhibiting drug resistant cancer cells. The lipid, formed by conjugating dodecylamine to d -phosphotyrosine, self-assembles to form micelles. Enzymatic dephosphorylation of the micelles inserts the lipids into membranes and increases membrane tension. The micelles effectively inhibit a drug resistant glioblastoma cell (T98G) or a triple-negative breast cancer cell (HCC1937), without inducing acquired drug resistance. Moreover, the enzymatic reaction of the micelles promotes the accumulation of the lipids in the membranes of subcellular organelles (e.g., endoplasmic reticulum (ER), Golgi, and mitochondria), thus activating multiple regulated cell death pathways. This work, in which for the first time membrane tension is increased to inhibit cancer cells, illustrates a new and powerful supramolecular approach for antagonizing difficult drug targets. 相似文献
69.
Nowadays, pharmaceutical antibiotics are known as a serious class of pollutants. Therefore, it is important to develop effective methods for removing these pollutants from aqueous media. Different methods were applied for this purpose, and among these methods, chemical reduction by a cheap and eco‐friendly nanocatalyst is the most efficient and simplest method. In this research, based on graphene oxide supported by zero‐valent iron in mono‐, bi‐, and tri‐metallic systems, various nanocomposites were synthesized and used to degrade tetracycline as a model antibiotic from aqueous media. An investigation was carried out on the synergic effect among graphene oxide and the nano zero‐valent iron‐based tri‐metallic system as well as removal efficiencies. It was found that higher degradation efficiency is yielded by graphene oxide supported by Fe/Cu/Ag tri‐metallic system. The maximum synergic effect occurs at an acidic medium. The Brunauer–Emmett–Teller, Fourier transform spectroscopy, scanning electron microscopy‐energy dispersive X‐ray analysis, transmission electron microscopy, and X‐ray diffraction analysis were used to characterize the synthesized nanocomposites, which has successfully proved the loading of nanoscale Fe/Cu/Ag tri‐metallic on a graphene oxide support. The central composite design was used to model and optimize all involved variables affecting antibiotic removal efficiency. The consequences illustrated the optimum condition regarding the removal of 50 ppm of tetracycline, for the nanocomposites dose of 3.0 mg ml?1, the contact time of 30 min, and pH of 2, was achieved using the simplex non‐linear optimization method. Moreover, antibiotic adsorption kinetic models were also investigated. Finally, the tetracycline removal from aqueous media at different concentrations, 25, 50, and 75 ppm, was successful by applying the proposed nanocomposite, and the results showed tetracycline removal efficiencies of above 70%. 相似文献
70.
Meccanica - In the present study, the effects of wall roughness on the dynamic of laminar electro-osmotic flow (EOF) between two parallel plates have been investigated numerically. The governing... 相似文献